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Future research should investigate whether HMB supplementation during weight loss induced by GLP-1RA can mitigate the loss of lean muscle mass

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Semaglutide 2.4 mg (Wegovy) and tirzepatide 15 mg (Zepbound) are covered only if the employer or plan sponsor specifically purchased the "obesity pharmacotherapy benefit rider." According to Anthem's 2025 benefit design survey, 41% of fully insured commercial groups elected this rider, up from 28% in 2023