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Figure 2 Bidirectional interactions between gut microbiota and GLP-1 receptor agonists in metabolic regulation
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However, as discussed by others, inhibition of the glycerophosphate shuttle alone may not be sufficient for a sustained impact on gluconeogenesis because the malate/aspartate shuttle will compensate unless the mitochondrial membrane potential (which is maintained by the respiratory chain) also becomes suppressed [19]
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