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Other examples of potential functional interactions might include the receptor for long-chain saturated fatty acids, FFA1, which is also expressed in pancreatic beta cells, where its activation leads to GSIS potentiation via Gα q transducer pathways (Kimura et al., 2020), as well as in hepatocytes (Secor et al., 2021) and enteroendocrine L and K cells, where it contributes to incretin hormone secretion, with FFA1 KO mice exhibiting obesity on a low-fat diet (Lu et al., 2021)
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